Vegetation activity usually reveals some features expressed as dynamic and nonlinear due to climate change, which is mainly characterized as temperature warming. Furthermore, the interaction of multi-factors and multi-processes, and the complex impacts of vegetation activity on climate change are presented, and the features of spatial heterogeneity are reflected. First, research progress on the pros and cons of global warming, and the influence of precipitation variation on vegetation activity are summarized in this paper. A certain degree of temperature and precipitation increase is conducive to enhanced vegetation activity. However, many studies have shown that there will be an adverse impact on vegetation activity if the temperature rises more than 3℃ or the amount of precipitation changes by about 50%; however, the thresholds of key responses to climate change and the problems of vulnerability are still unclear. Then, the coupling effects of climate multi-factors on vegetation activity were analyzed. The processes of vegetation activity are influenced by combinations of climate factors, such as water, heat, and light. In particular, warm and wet conditions are most beneficial to vegetation activity. However, the synergistic effect of different climatic condition affecting in vegetation activity process is still difficulty to explain in the study. Finally, the spatial heterogeneity of vegetation activity in response to climatic factors in different regions, and the impact on the distribution of the vegetation zone were noted. For example, vegetation activity in northeast China was more sensitive to temperature, which may shift the forest boundary northward. However, in Western Inner Mongolia, the response to precipitation became dominant and the prairie was degraded. Overall, according to the geographic logic of "process and pattern coupling" in the future, many methods, such as application statistics, experiments, and models, should be integrated in order to enhance study on the spatial heterogeneity of vegetation activity responses to climate change.