The optimization of regional water resources via regulation of trade and consumption has been considered as an alternative to alleviate the severity of water shortage. The multiregional input-output (MRIO) analysis makes it possible to explore virtual water trade among regions. This study established a virtual water accounting model for the Jing-Jin-Ji region based on the MRIO, combining the economic input-output table and sectoral water consumption in 2012. The import and export of virtual water for different regions and sectors were analyzed by calculating the direct water use coefficient, total water use coefficient, the final consumption of virtual water, and virtual water trade volume. The results show that the Jing-Jin-Ji region is a net virtual water exporter. Main net exporters of virtual water include the service and transport sector in Beijing and the manufacturing and agricultural sector in Hebei. From the perspective of the driving coefficient, manufacturing, construction, services, and transport in Jing-Jin-Ji region have high cumulative water input, but low direct water input, implying they need more indirect water inflow from other sectors for production. Moreover, it is evident that the agricultural and manufacturing sector in Hebei has high virtual water outflow, indicating that these should be the key sectors for water-saving management through reducing water consumption from both direct and indirect perspectives. By investigating direct water consumption, indirect water consumption, water use coefficients, driving coefficients, and the virtual water trade among sectors in the Jing-Jin-Ji region, we could identify the key sectors and pathways for water consumption and thus provides a solid foundation for virtual water trade strategies to alleviate water resource pressure in the Jing-Jin-Ji region.