Forest loss and fragmentation have long been one of the most vital concerns of the international community. Landscape fragmentation includes five different spatially explicit processes:perforation, dissection, subdivision, shrinkage, and attrition. Following this theory, a forest fragmentation process model that can detect these spatially explicit processes, as well as the ecological consequences of forest landscape fragmentation, was developed using ArcGIS Modeler. Using the National Land Cover Database (years 2001, 2006, and 2011), the forest fragmentation process model was applied to Washington and Mississippi in the USA. Deforested patches were quantified and categorized into one of four fragmentation processes, by merging the dissection spatial process into the subdivision spatial process (because of its principal linear feature). Furthermore, the spatio-temporal differences in fragmentation pattern between natural forests and plantations were compared. For natural forests, forest fragmentation mainly occurred in the urban/forest, cultivated/forest, and shrubland/forest interfaces, whereas the pattern of deforested plantation patches dispersed sparsely and irregularly throughout the region. The subdivision and shrinkage patches in natural forests usually followed the perforation, subdivision, and shrinkage patches of the previous period. In contrast, for the plantations, the spatial transition relationships of the four fragmentation processes were not as apparent as for the natural forests. Nonetheless, for both natural forests and plantations, the overall temporal fragmentation pattern tended to have a similar "shrinkage-attrition-perforation/subdivision" tendency. This tendency was characterized by an early shrinkage dominance, followed by its gradual disappearance. Furthermore, perforation and subdivision components increased gradually, and a new dominance was established accordingly.