Soil salinization is the main obstacle to agricultural development in arid and semi-arid regions. It is also one of the key limitations on the growth of eremophytes, which seriously affect the stability and safety of the ecological environment in oases. Oases are unique among desert ecosystems because of the availability of generally sufficient water resources that can sustain a wider range of human activities. Over time, oases often become highly developed locales in arid and semi-arid regions, with concentrated human populations and activities. With the development of oasis irrigation agriculture, soil salinization and soil secondary salinization caused by irrigation has gradually become the largest obstacle for sustainable oasis agricultural development. Study of the distribution of soil salt content in soil profiles can determine the influence of salinization on oasis ecology and environment. In this study, using the Weigan-Kuqa Delta Oasis as the research area, the soil electrical conductivities of typical plots in the region were obtained using an electromagnetic induction technique and a traditional soil sampling method. A linear mixed model between magnetic inductive apparent conductivity and the observed conductivities of the soil samples indicates that the apparent electricity conductivity is a good surrogate for soil salinity. We therefore used the apparent soil electricity conductivity to examine the spatial distribution of soil salt content at different depths in the soil profile because obtaining such data is often much more cost-effective. We employed a natural neighbor interpolation approach at various depths to analyze and evaluate the spatial distribution features of the soil profile salinity. The results showed that the soil in the research area has strong surface aggregation and spatial variation, and that the soil body is moderately salinized. Soil salinization is clearly higher in the desert areas and interlaced border areas than within the oasis. Soil salt content showed a decreasing trend from the desert areas and interlaced border areas to the internal oasis. The three linear mixed models, built based on soil electrical conductivities and magnetic inductive apparent conductivities of the soils at each depth, all reached the 0.01 significance level. Both the vertical and horizontal apparent electrical conductivities were significantly related to the spatial distribution of soil salt content in soil profiles. Further exploration indicates that the horizontal apparent electrical conductivity best measures the surface soil salinization, while the vertical apparent electricity conductivity best measures the deep soil salt content. Additionally, combining both the horizontal and vertical apparent electricity conductivities produces more efficient interpretation of soil salinization and better spatial interpolation results than either method alone. The result of the natural neighbor interpolation visually reflects the spatial distribution status of the soil profile salinity in the research area. The interpretation models of soil salinity obtained by combining horizontal and vertical modes can effectively increase the prediction accuracy of the spatial distribution of soil profile salinity. Through intensive field work and soil sampling practices, coupled with a local spatial interpolation approach (the natural neighbors), this study investigates the feasibility of applying electromagnetic induction devices to evaluating, monitoring, and predicting soil salinization at various soil depths in the Werigan-Kuqa Delta Oasis. Our results show that the spatial distribution of soil salinization significantly contributes to efficient local soil salinization management and possible treatment, and thus can provide technical support for preventing and controlling soil salinization in this region.