Grazing, fencing, mowing and burning are the most frequently measures in native grassland management. Grassland plant disease is one of the main limiting factors of grassland productivity. Considering the ecological and economic benefits, analyze the effects of grassland use methods on native grassland plant disease, and then take reasonable management practices, to effectively reduce the loss caused by grassland plant diseases, therefore improve grassland productivity and function of ecological service. This paper reviews the research progress in China and abroad by 2014 on the livestock grazing, fencing, mowing and burning on the diseases of native grassland plants. Grazing has dual influence on the occurrence of grassland plant disease. It removed diseased plant by food intake, reduced the original source of infection and decreased the happen of most plant disease, but it spread plant pathogens by food intake as well and caused the epidemic of physical transported plant disease. Fencing increased plant disease occurrence by increasing plant species abundance and reducing plant diversities. Mowing can prevent further invasion and colonization of fungi, thereby reducing the occurrence of grassland diseases. However, mowing can also produce conditions conducive to the spread of pathogen spores, and pathogenic fungi can spread from cutting tool blades to the wounds created by mowing; these conditions also favor invasive plants. Burning in winter and early spring could remove litters and reduce over winter pathogens, therefore decrease the incidence of plant disease. Suggestions and prospects for study of grassland plant disease management were developed for future research.