In recent years, ecological security has emerged as a prominent issue in environmental research, and is a major strategic factor in sustainable development. Guangxi is one of the more important region in western China, and the problems it faces in terms of ecological security are significant. The major strategic tasks of China's western development are to strengthen environmental protection and reconstruction, maintain ecological safety in Guangxi and the entire western region, and construct a western ecological security barrier. It can be argued that the maintenance of ecological safety in Guangxi and achievement of ecological security in the western region are concrete actions that will safeguard the ecological security of the country. Thus, in-depth study of ecological safety in Guangxi has important environmental, economic, social, political and international meaning. For a considerable time, the Guangxi border region has been a typical underdeveloped area, with poor infrastructure, lack of strong support for the policy, and a weak sustainable development capacity. The area is now looking to the State to increase policy support for the Guangxi Regional Development Contiguous Areas that are suffering particular difficulties. Such fiscal and land policy support would include poverty alleviation, increased investment in water conservancy, energy and construction investment, and ecological compensation. Guangxi has more recently been faced with major problems in terms of ecological security and challenges to sustainable development. These include environmental damage in the form of soil erosion and recession, desertification, vegetation degradation, reduced biodiversity, invasive species and pollution. The fundamental human causes of these conditions include poor production activities, improper wastes discharge, and excessive population growth. Frequent natural disasters also play a major role. Guangxi is a disaster-prone area, and to varying degrees, natural disasters occur every year, causing damage to land and people's property, and claiming the lives of animals and humans. Natural disasters and development activity are serious ecological safety issues in themselves, but they will also trigger other environmental consequences and even more serious ecological security problems. Frequent, large-scale natural disasters in Guangxi, make Guangxi ecological security issues more complex, volatile and unpredictable. Timely, strategic and targeted policies must be developed and implemented in response to the ecological security problems in Guangxi. Moreover, only by taking a comprehensive approach to support policies and measures will sustainable development in Guangxi likely succeed. The list of interventions include: (1) enhancing awareness; (2) improving institution; (3) strictly enforcing laws and regulations; (4) conducting green appraisals; (5) implementing ecological compensation; (6) strengthening research; (7) promoting cooperation; (8) instituting a zoning classification system; (9) increasing investment; and (10) building capacity. By recommending the above series of policies and measures, we hope to enhance the ecological and environmental protection capacity in Guangxi, and improve the area's capacity for sustainable development. The ultimate goal is to achieve ecological safety and bring about a coordinated and healthy development of Guangxi's economic, social and environment resources.