In this study, spatiotemporal variation of soil moisture was investigated on six manipulated land use types, i.e., burning, cutting, cutting plus root removal, enclosure, maize field, and sward of Guimu No. 1.Each land use type covered an area of 20 m×70 m on a typical slope in depression between karst hills. Soil moisture was measured with 5 m × 5 m sampling grid and was analyzed through classical statistics and geostatistical methods. Soil moisture was high in depression between karst hills, and was significantly higher in rainy season than in dry season. In rainy season, soil moisture changed in the order of burning > enclosure and cutting plus root removal > maize field and sward of Guimu No. 1 > cutting, while in dry season, soil moisture changed in the order of cutting, burning, cutting plus root removal > sward of Guimu No. 1andexclosure > maize field. Soil moisture varied moderately or strongly, and the variation was larger when the soil moisture was lower. All autocorrelation coefficients of soil moisture under different land use types tended to change from positive to negative direction but with different inflection points and the values were larger in dry season than in rainy season. The best fitted models of soil moisture differed under different land use types, but all showed moderate or strong spatial correlation. The spatial variation rangedfrom 6.8 to 213 m and was larger in dry season than in rainy season. The spatial pattern of surface soil moisture under the same land use type in rainy season was similar to that in dry season, while spatial pattern of surface soil moisture varied among different land use types. Therefore, diverse strategies in the utilization of water resources should be adopted during ecological restoration and vegetation reconstruction in depressions between karst hills.