The Landscape Ecological Security Pattern Optimization Approach (LESPOA) is an effective way of promoting healthier ecosystems and harmonious relationships between people and their surrounding environment. Currently, there are shortcomings to this approach because it lacks objectivity in ecological site selection, and when simulating ecological resistances, it doesn't consider the interactions between these resistances. In order to address these issues, this paper uses the granularity inverse method and the comprehensive construction method of ecological surface resistance, which combines the technology of GIS with a least-cost distance model, to apply the LESPOA in Xiuying district. We aimed to provide a scientific basis for ecological environment construction and a method for improving the LESPOA. The results were: (1) When the granularity of ecological landscape component is 400 m, the ecological landscape component is an appropriate method for selecting ecological sources. According to the above appropriate method, there were 18 ecological sources (8 primary and 10 secondary), 17 ecological corridors, and 11 ecological nodes in Xiuying district. The reference scale of new ecological sources was 38.5 hm². The maximum ecological service distance for whole ecological source structure was about 800 m. When the distance between different ecological patches is approximately 200 m, we should enhance the ecological connections between them. Currently, there are 11 non-ecological landscape patches (with a total area of 20.26 hm²) in Xiuying district that need to be converted to ecological landscape patch;(2) The granularity inverse method has a stronger theoretical basis and greater objectivity than traditional methods of ecological source selection, and it also can reflects the connective characteristics of landscape pattern. Therefore, the results from this method can supply more accurate references for ecological construction than traditional methods. (3) The comprehensive ecological resistance surface considers the interaction between resistances and thus can better simulate the physical characteristics of ecological resistances than the traditional ecological resistance surface that just considers land use type. There are significant differences between dominant ecological resistance and recessive ecological resistance, which can reflect potential ecological weak points. Most of the ecological weak points in Xiuying district are woodlands that are surrounded by farmland, unused land, and construction land. Although these ecological weak points can easily be neglected, it is important to focus on enhancing the connections between the weak points and ecological sources in order to restore natural ecologic processes.