To investigate the impact of reclamation on the landscape pattern of coastal wetlands in Yancheng, northern Jiangsu of China, RS, GIS and FRAGSTATS technologies were applied to analyze the remote sensing data from 1973 to 2013 as basic information resource. Changes of landscape between reclaimed and unreclaimed zones in the national nature reserve of Yancheng, were compared and analyzed from Chuandong Port to Xinyang Port, especially among Haifeng, Haibei and Jinfeng reclamation sites. Characteristics of the reclamation in studied areas from 1973 to 2013 were concluded as follows by a 10-year time interval: Firstly, the ranges of reclamation were stripped in shape, parallel to the coastline, and advanced offshore with width narrowing gradually. Secondly, the difficulty of reclamation increased progressively, and the overall intensity of reclamation showed a decrease tendency while the areas hovered unsteadily during its processes. Thirdly, the land use types diversified remarkably after the reclamation, which were mainly crop cultivation and aquaculture. Consequently, it was found that in the unreclaimed zone I, the natural vegetation area increased by 4762 hm², the patch shape tended to be more complex or irregular, FRAC_AM increased from 1.10 to 1.15, and the degree of landscape fragmentation remained low between 0.17 to 0.21 while the landscape diversity increased from 1.11 to 1.52. On the contrary, in reclamation zones II, III and IV, the natural vegetation area increased by 9873 hm², 13788 hm² and 6890 hm², the patch shape tended to be more simple or regular, FRAC_AM decreased by 0.03, 0.03 and 0.02, and the degree of landscape fragmentation increased by 0.21, 0.23 and 0.17 while the landscape diversity firstly increased and then decreased by 0.8 and 0.5 respectively. Though the changes of landscape areas and the shape of patches in single reclamation sites were similar to that of the whole reclamation zone, landscape fragmentation primarily increased and then decreased. The natural landscape was progressively transformed into artificial landscape, and the patch shape tended to be more simple or regular in Haifeng, Haibei, while more complex and natural in Jinfeng. Meanwhile, the changes of fragmentation were distinctive form each other that, the tend of which were "up-down-up", " down-up- down" and "up-down", respectively. Before reclamation, the differences between the changes of landscape area and patch shape were neglectable, but was significant in the landscape fragmentation. Landscape pattern changes were similar among Haifeng, Haibei and Jinfeng during the period of land reclamation, and that of each site maintained the condition at the end of reclamation, except in the presence of a new round of human disturbance.