Porphyra yezoensis is an economic marine macroalgae cultivated widely along the coast of the Yellow Sea, China. In this study, the effects of algal density (0.1, 0.2, 0.4, 0.8, and 1.6 g/L), irradiance (30, 60, 90, and 120 μmol m^-2 s^-1), temperature (5, 10, 15, 20 and 25 ℃), photoperiod (8: 16-h, 12: 12-h, and 16: 8-h light: dark: D]), salinity (10, 15, 20, 25, 30, and 35), and desiccation time (0, 1, 2, and 4 h) on the growth and nutrient removal capacity were assessed in the laboratory to study the bioremediation potential of large-scale P. yezoensis cultivation. Each experiment was conducted for 2 weeks. About 3-week-old algae of length 3-5 cm were used. P. yezoensis thalli were grown in gently aerated 250-ml bottles. Von Stosch enrichment (VSE) solution was added to the culture medium containing approximately 500 μmol/L NO₃^--N and 30 μmol/L PO₄^3--P. The culture medium was renewed twice a week; biomass was recorded as the fresh weight and the NO₃^--N and PO₄^3--P contents in the culture medium were measured. The results indicated that the growth rate of Porphyra showed a negative correlation with algal density and a positive correlation with irradiance. In 2 weeks, the maximal algal growth rate of 38.1% was observed, with algal density of 0.1 g/L at an irradiance of 120 μmol m^-2 s^-1. The minimal algal growth rate of 12.6% was observed, with an algal density of 1.6 g/L at an irradiance of 30 μmol m^-2 s^-1. The removal rates of NO₃^--N and PO₄^3--P increased with increasing algal density ranging from 0.1 g/L to 0.8 g/L, whereas no significant differences were noted when the algal density ranged from 0.8 g/L to 1.6 g/L. At an algal density of 1.6 g/L and irradiance of 90 μmol m^-2 s^-1, the maximum NO₃^--N and PO₄^3--P removal rates were 97.3% (1.74 mg N/d) and 93.7% (0.21 mg P/d), respectively. The following conditions were optimal for the growth and nutrition removal: temperature of 15 ℃, photoperiod of 16: 8-h L: D, and salinity of 25. At the above optimal conditions, the maximum growth rate of 36.9% was noted, with the highest NO₃^--N and PO₄^3--P removal efficiencies. However, at 25 ℃ and photoperiod of 8: 16-h L: D, the minimum growth rate of 7.5% was noted, with the lowest NO₃^--N and PO₄^3--P removal efficiency. P. yezoensis could grow in a wide salinity range, from 10 to 35. The maximal growth rate of 37.9%, with the maximum NO₃^--N and PO₄^3--P removal rates of 96.5% (1.70 mg N/d) and 86.9% (0.20 mg P/d), respectively, were observed under 25 salinity and no desiccation (0 h). Although desiccation treatment had a negative effect on the growth and nutrition removal rate, it strengthened the physiological activity. The growth rate and nutrient removal efficiency of no-desiccation groups were higher than those in desiccation groups. Further, low salinity and long desiccation time greatly inhibited algal growth and nutrient uptake; however, the photosynthesis rate in desiccation groups was higher than that in no-desiccation groups. Overall, P. yezoensis showed rapid growth rate, high commercial value, and efficient nutrient concentration, making it an excellent candidate for bioremediation. The study results may be useful for applying P. yezoensis for remediation in coastal waters worldwide.