Tetracycfine (TC) is one of emerging pollutant pharmaceuticals and personal care products (PPCPs) and belongs to tetracycline antibiotics. Due to TC was broadly and largely applied in livestock and aquiculture, it was easily remnant in environment and showed some potential environmental risks. This article reviewed the resoures of TC in environment, the eco-toxicities of it to micooganism, animal and plant, the residue of it in soil and water and its degradation. The result showed that the concentration of TC in soil piled with animal manure near the livestock farm was very high. In addition, the TC residue in soil fertilizered by animal manure was also higher. However, TC concentrations in most soils without animal manure fertilizered were only as background levels. The residue of TC in soil was mostly in topsoil. The eco-toxicity of TC to soil was mainly focused on microorganism, but seldom on the plant root and soil animal. The roles of TC to soil microorganism were influenced by two important factors, i.e. TC concentration and some soil factors such as soil organic matter varieties and contents, mineral type, pH and so on. Normally, the sensitiveness of monad to TC was higher than that of multicellutar organism. In different water environments, there were really some TC residues. Usually, direct surface runoff and aquiculture were mainly resources of TC in water. Though the researches of TC ecotoxicity to biologies in water were much wider than that of it in soil, most studies were the short time toxicity effect based on some physiological indexes such as growth, dead and breed. As for the studies of TC to aquatic organism, especially on its physiological, biochemistry and molecular indexes were seldom. Although TC can be degraded in soil environment through a series of degradation reactions such as hydrolysis, light degradation, micro-biological degradation and so on, there were not too much reports concerning TC degradation in soil. Some researches about TC degradation were documented only in compost. By contrast, the studies on the removal of TC from water were abroad but most of them were only aimed at adsorbents such as bentonite, kaolin soil, aluminium hydroxide. Other removal methods like oxidizing agent KMnO₄, lignin peroxidase (Lip), ozone, biology filter membrane, aerate pond, etc. were showed better effects either. TC in soil and water may produce different degradation products under different environmental conditions. Under the level of laboratory, TC may produce transferlate reversible isomer, i.e. its anhydrotetracycline (ATC) and epianhydrotetracycline (EATC) may interconverse when some conditions were perfect. However, the reports concerning the eco-toxicities of TC degradation products were seldom and contradictory, which may be caused by the different research conditions and not too deep research on TC degradation. Slather TC caused the increase of tolerant bacterial population in animal body. These drug resistant strains may enter to soil through maure pathway and planting in soil. They may also further migrate to surrounding soil and water through direct surface runoff and influent. The drug resistant strain may threaten the safeties of food and drink water even human health due to its diffusion in original inhabitant microbe. The resistant level of micoorganim to TC may be largely increased by the long time applying fertilizer with animal manure, which may cause to some potential environment risks. It was suggested that the directive toxicology of TC to animal and plant is low even with a high concentration level. The study of resistance gene caused by long time residue of TC in soil even in water may be an important research field in the future.