The meteorological data from1961 to 2010 about the Lancang region which was provided by National Meteorological Information Center were used to to explore the link between the variation of the Lancang River Basin extreme weather disasters in the late 19th century to the early 21st century, and its regional extreme disasters change and global climate change the method whose using wavelet analysis, EMD decomposition, CI index, mean generating function stepwise regression model, mutation testing and correlation analysis etc were been used. It is showed that by the results: (1) Annual precipitation is stabilized, rose slightly, but the rate of rise is small, only 3.1848 in the 50-year period of which from 1951 to 2010. Annual precipitation anomaly maps to reflect regional differences in precipitation in the south than in the north, between positive and negative anomalies between -2 to 2, the probability of occurrence of the northern arid. (2) In the past 20 years, the Lancang area arid the number was significantly increased by the Lancang River Basin annual rainstorm frequency times in the past 50 years and the next 20 years there is no obvious increase trend, drought frequency times the next 20 years showed a slope of 0.2635 the rising trend, the future of the region of extreme weather disasters, mainly drought disaster. (3) There have multi-scale features about regional precipitation and storm frequency, whose 2a, 7a, 15a change cycle in Lancang River Basin precipitation has been proved by two research methods, but whose main cycle by two method is different. It is showed that EMD method is more suitable than wavelet method to deal with non-stationary, non-linear signal, concluded that the precipitation of the Lancang River Basin 2a, 7a, 15a change cycle, and primary cycle prevail 2a. (4) The cycle of IMF1 and IMF2 about precipitation and frequent rainstorms the degree sequence is between 2-7 a, which is coincided similar to that of ENSO. It was inferred by it that there is important connection between the storms and drought disasters of Lancang River Basin and ENSO. As the temperature increased significantly increased frequency of drought disasters, all of those showed that extreme temperature disasters, climate change and global warming have some connection to one of the manifestations of global climate change, regional response.