The purpose of the paper was to study the purple soil's physico-chemical characteristics, microbial populations, microbial properties, enzyme activities, and the relationships between them in different stages of re-vegetation on sloping-land in Hengyang of Hunan Province, South-central China. We took soils of 0-40cm depth in typical areas in Setaria viridi community stage (Ⅰ); Lagerstroemia indica-Setaria viridi community stage (Ⅱ); Vitex negundo var. cannabifolia+Robinia pseudoacacia community stage (Ⅲ); and Liquidamdar formosana+Melia azedarach-Vitex negundo var. cannabifolia community stage (Ⅳ) as our test objects by using the space series to replace time courses.The results showed that: (1) From Ⅰ, Ⅱ, Ⅲ to Ⅳ, the soil water content, total soil porosity, ratio of non-capillary porosity to capillary porosity, >0.25mm water stable aggregates content, SOC (Soil Organic C), TN (Total N), AN (Available N) and AP (Available P) increased significantly. In contrast, soil bulk density decreased significantly, pH decreased slightly, and there were no significant differences in TP (Total P), TK (Total K) and AK (Available K). The changes in the number of soil microbes, microbial properties and the soil enzyme activities have resulted from the differences in the soil physico-chemical characteristics. (2) The number of soil microbes increased significantly, with a significant increase in the number of bacteria, but the numbers of fungi and actiomycetes decreased significantly in the process of the succession. (3) The SBR (Soil Base Respiration), SMBC (Soil Microbial Biomass C), SMBN (Soil Microbial Biomass N), SMBP (Soil Microbial Biomass P) and Cmin/Corg increased significantly. The qCO₂ decreased significantly, and C/N decreased, with no significant difference in the process of succession. The activities of URE (Urease), INV (Invertase) and APE (Alkaline phosphatase) significantly increased in the process of the succession. (4) There were close correlations among the soil physico-chemical characteristics, the number of soil microbes, the soil microbial properties and the soil enzyme activities. This study will, to some degree, enrich the restoration ecology of this area and provide a theoretical basis for the re-vegetation and reconstruction of ecosystems on sloping land with purple soils in Hengyang of Hunan Province, South-central China.