In the rapid urbanization process, land use of the urban fringe changes dramatically, and the landscape fragmentation is particularly outstanding. Hence, exploration of landscape fragmentation pattern and its spatial heterogeneity of urban fringe area are helpful to grasp the change mechanism of landscape dynamic as well as its ecological problems. In this study, on the basis of the interpreted land use maps from TM imagery, we utilized a series of moving window analysis and geo-statistic methods combined with effective mesh size to investigate the spatial heterogeneity of landscape fragmentation in Shunyi district, Beijing. The study contents mainly include the scale dependency of spatial heterogeneity, spatial variation character of several typical scale, spatial patterns and its ecological processes on 1000m scale for landscape fragmentation. The results show that, 1) the landscape fragmentation of urban fringe area has obvious characters of scale dependency for spatial heterogeneity, which mainly caused by the spatial autocorrelation; the total spatial variation of landscape fragmentation is not obvious in 1992 and 1999, but in 2009 is very strong. According to the analyses of spatial variance characters at different scales and based on the land use structure of county-wide urban fringe area, we choose 1000 meters as a relatively appropriate scale for analyzing the spatial heterogeneity of landscape fragmentation. 2) During the research period, the spatial heterogeneity of landscape fragmentation shows an obvious upward tendency, and the fragmentation of land use patch is getting more and more serious, especially the fragmentation of arable land in the period of 1999-2009. 3) The high value area of landscape fragmentation shows the momentum of transferring from the east to the west, meanwhile its spatial pattern presents a remarkable feature of the agglomeration and dispersion, which similar attributes gather and otherness attributes gather, and this pattern presents a trend of aggravating. 4) The spatial autocorrelation effect of landscape fragmentation comes from high strength social economic activities, and it exhibits obvious location characteristics, which the radiation effect of the central city is strong and the transport network plays a very important promoting role. These research results can provide a reference for land planning, urban planning and landscape ecological construction. In addition, the multi-view research of landscape pattern and its ecological processes are still necessary to be deepened.