Cadmium (Cd) is one of the most toxic pollutants in the environment. Agricultural soils in several locations of Sichuan province in China are slightly to moderately contaminated by Cd that creates risk for animal and human health through food chains. Thus, how to minimize Ca uptake by crops and to produce safe agricultural products are highly concerned by the government and the society. Our previous work had examined the effects of macro-nutrients (nitrogen, phosphorus and potassium) on Cd uptake by wheat and rice. It indicated that different forms of these fertilizers do affect Cd uptake by wheat and rice in the ways of enhancement, reduction or no effect. The results encouraged the authors to further research the rest of the plant necessary nutrients and beneficial elements commonly used in agriculture. This study, therefore, aimed to continue examining effects of secondary, micro- and beneficial elements on rice growth and Cd uptake from a soil moderately contaminated with Cd in a pot experiment. The experiment consisted of twenty one treatments including both sulfate and chloride salts of calcium (Ca), magnesium (Mg), iron (Fe), manganese (Mn), zinc (Zn) and copper (Cu), and elemental sulfur (S), calcium carbonate as a third form of Ca carrier, borax and boric acid as two sources of boron (B), sodium selenite (Se) and sodium silicate (Si) applied into soil or as folia spray. All the treatments repeated four times. The results showed that folia application of sodium silicate significantly increased rice grain yield, while calcium carbonate, boric acid and sodium silicate incorporated into soil significantly reduced rice grain yield. The chloride salts of Mg, Zn and Fe were more favorable to enhance rice grain yield than the sulfate salts of the three elements, while the sulfate salts of Ca and Cu just behaved in an opposite manner. Among the three secondary elements of Ca, Mg and S, Ca enhanced but Mg and S in particular reduced the concentrations and uptake of Cd in grain. In straw, the concentrations and uptake of Cd were minimized by magnesium chloride and S in particular. It was found that Mg retarded transferring Cd from straw to grain, with magnesium chloride more effective than the magnesium sulfate. Among the micro-elements studied, Zn was most effective in blocking Cd uptake by rice, and followed by Cu, while folia application of the beneficial element of Si as sodium silicate topped the all the treatments in concentrations and uptake of Cd in grain. The treatments of ferrous sulfate, magnesium chloride, cupper chloride, boric acid and borax effectively depressed but the treatments of Zn and folia application of sodium silicate promoted the transfer of Cd from straw to grain, indicating the mechanism of Si blocking Cd uptake by rice was most likely to occur in soil rather than within plant or in the aboveground portions of the plant. It implies that selecting appropriate forms of secondary, micro- and beneficial elements and using proper application methods could effectively reduce Cd uptake by and Cd content in grain in the Cd polluted soil.