Dynamics of germination rate (GR), malondialdehyde (MDA), free proline (Pro), soluble sugar (SS), superoxide dismutase (SOD) and peroxidase (POD) were analyzed during seed germination of Glycyrrhiza inflata under drought stress simulated by polyethylene glycol (PEG)-6000. The Results showed that, GR was 100% under -0.1MPa of water potential then decreased when the drought stress intensified; MDA, Pro, SOD and POD increased when water potential≥-0.2MPa but then decreased when -1.4MPa ≤ water potential < -0.2MPa (P<0.05). The correlations among the aforementioned four indexes were significant (P<0.05), while the drought stress increased SS significantly at P<0.05.