Urban wetland is an important component of the urban ecological security system, and also is a hot topic of wetland study. This paper took Shenzhen City as an example, using multi-temporal remote sensing data and land-use survey data to build the multi -temporal wetland landscape maps through visual interpretation processes, analyzed the wetland landscape changes and driving forces in the context of urbanization. The present study included three aspects of analysis, i.e. the relationship between the change of wetland structure and the expansion of built-up area, spatial variation of the changes, and landscape transfer characteristics among different wetland types and between wetland types and non-wetland land-use types. This study showed that 35.7% of the total wetland area lost during the study period in Shenzhen City. The wetland changes varied with wetland type and administration units. Built-up area expansion, functional differences among wetland types, and the differences in regional socio-economic as well as natural environments were the three major driving forces of the change. The built-up area expansion was the major cause of the wetland loss in the study area, and its impact showed a non-uniform process. Functional difference was the major reason causing the differences in landscape change among wetland types. In addition, regional socio-economic and natural environmental differences possibly are among the major factors leading to the differences of wetland dynamics among different administrative units.