Effects of corn stalk on wheat seedling, contents of Pb and protein in mature grains as well as yield properties were studied in polluted soil of Pb by in-door and out-door pot experiments. At the same time, the physiological mechanism of alleviating toxicity of Pb to wheat by corn stalk was investigated in detail. The results showed that the growth of wheat seedling was significantly promoted by adding 3g/kg and 6g/kg corn stalk into the Pb polluted soil and the toxicity of Pb to wheat was also effectively alleviated. Detailedly, compared to the control, the root length, shoot length, dry weight of plant, chlorophyl content and root activity increased by contraries of the activities decreasing of peroxidase(POD) and superoxide dismutase(SOD) isoenzymes as well as malondialdehyde(MDA) content. What is more, the corn stalk could reduce the content of Pb in grains and enhance the grains protein content and biological yield.