Solidago canadensis, a perennial plant native to North America, is now spreading rapidly in China, especially in eastern China. The plant has already induced serious threats to native ecosystems and biodiversity and has caused considerable economic loss to those areas. A spatial analysis technique was used to analyze the spatial distribution pattern of Solidago canadensis in Zhejiang Province in 2005. A stepwise regression method was applied to explore the relationship between the spatial distribution pattern of Solidago canadensis and anthropogenic activities. Our results indicate that there is a significant spatial heterogeneity of Solidago canadensis areal distribution in the study area. Imports and intensity of agricultural activities are major factors in Solidago canadensis occurrence area, while length of highways accounts for the variance in relative area of Solidago canadensis. With a rapidly developing economy, more attention should be given to the negative impact of Solidago canadensis on the environment. In terms of prevention and control Solidago canadensis invasion, the reclamation of abandoned and idle land should be intensified so as to limit establishment from points of origin.