The security of ecosystems (eco-security) has become a primary goal of national safety in China, and has become the most important content for sustainable development investigations of the Guangzhou region and the nation as a whole. Based on the eco-security digital assessment figures, landscape index and semivariable function methods were used to study the landscape patterns and dynamic characteristics of Guangzhou, as views from class distribution and space construction. The landscape index showed that the eco-security of Guangzhou is mainly in a moderate level now. Though damaged in 1995, eco-security has begun to improve. From the aspects of fragmentation-complexity of shape and multiformity for landscape-the eco-security audit showed it obviously changes in time and space. The results of the semivariable function investigation showed that eco-security had a high predictability, and there should be a different grading structure for assessing eco-security in the research district.