Climatic factors are important conditions for tobacco growing. Therefore, many studies focused on the influence of climatic factors on tobacco quality. However, the studies on climatic feasibility of tobacco with different transplanting dates were few. In this paper, the climatic state of flue-cured tobacco with different transplanting dates was analyzed, and the climatic feasibility indexes (CFI) were estimated for tobacco-growing areas in Hubei. Analyses were conducted on similarity between climatic conditions of tobacco at different transplanting dates suggested for different regions in Hubei and corresponding climatic conditions in foreign high-quality tobacco-growing areas. The results were as follows: (1) When daily air temperature increased steadily to above 15℃, 18℃, 20℃ and 22℃, CFIs for flue-cured tobacco at different transplanting dates were 0.863±0.06, 0.848±0.06, 0.855±0.07 and 0.890±0.05, respectively, indicating that transplanting date was the important factor to affect tobacco quality. (2) The transplanting dates were determined for 24 tobacco-growing counties in Hubei. In sites such as Lichuan, Wufeng, Laohekou, Xingshan, Yunxi, Fangxian, Zhushan, and Changyang, tobacco seedlings were suggested to transplant when daily air temperature steadily passed 18℃. In Xuan’en, the reasonable transplanting date of tobacco seedlings was when air temperature passed 20℃, while the transplanting date was when air temperature passed 15℃ in other 15 sites. (3) The similarity of the climatic conditions of flue-cured tobacco at different transplanting dates suggested for tobacco-growing areas in Hubei with corresponding climatic conditions in Brazil and Zimbabwe was higher than that with climatic conditions in America. The similarity analysis may be used as a reference to make full use of the natural resources in Hubei.