Insect migration is not only an adaptive behavior strategy which has evolved independently in the complicated and uncertain environment in most insect orders, but also is a key factor which induced the population abundance as well as infestation. This behavior is regulated not only by the environmental conditions but also the insect physiological factors. At present, many research progresses focus on the regulation mechanism of ecological environment, physiological factors, behavioral and genetic bases of insect migration. With the development of molecular biology technology, the molecular regulation mechanism resulted in insect migration has been paying more and more attention. Based on the summary of main regulation mechanisms of insect migration, perspectives and progress of new molecular mechanism underlying the regulation of insect migration are discussed.