Combined pollution is the main form of soil contamination, i.e. including heavy metals and organic pollutants, constitute the main form of soil contamination. For example, the coexistence of lead and cadmium in soils can interact with each other and consequently increases cadmium mobility. The application of simple physical, chemical and biological remediation methods in combined pollution sites is not satisfactory to mitigate the pollution. Therefore, a combination of different techniques is required to remediate these sites with multiple pollutants to enhance the remediation efficiency and at reasonable cost. Recent example indicates that the combination of chemical oxidation and ultrasonic techniques can transform toluene and xylene in soil into CO and CO2 in very short time. Progress to-date on the effective combination of different techniques to mitigate the soils with multiple pollutants has been discussed in the paper.