We simulated the impacts of breeding herd size, reproductive skew and numbers of breeding stags on the inbreeding coefficient of Père David’s deer. We found coefficient of inbreeding will increase in close breeding populations. The smaller the effective population and faster the coefficient of inbreeding will increase. The fewer the dominant breeding stags, the smaller the effective population. The impact of mating tactics on maintaining genetic diversity in Père David’s deer is limited. The big the variance of offspring produced, the smaller the effective population. Thus, we should adapt population management measures to preserve the genetic diversity in Père David’s deer. Based on our simulations, we suggested (1) to check the genetic back ground of each breeding Père David’s deer and to establish the genetic pedigree file for them; (2) At least two breeding herds should be maintained at each Père David’s deer breeding base, we should isolate these deer with close relationship when establish breeding herds; (3) Because Père David’s deer has a harem breeding system and the number of offspring each breeding individual have is not equal, each breeding herd should have approximately the same number of stags and hind and should not be too large; (4) We should pay special attention to maintain all genetic diversity in the source population while striving for have representativeness of genetic diversity in relocated population when we relocate Père David’s deer.