The impact on the environmental system of the Qinghai-Tibet Plateau of human activities keeps growing. Under the background of construction of the Qinghai-Tibet Plateau national park cluster, studying the environmental stress intensity and spatial effects of human productional and living activities is the scientific foundation for the precise implementation of environmental management and control and for the standardization of protection and utilization. This is of great significance for enhancing the sustainable development capacity of the Qinghai-Tibet Plateau. Taking Sanjiangyuan region as an example, based on the calculation of 4 types of anthropogenic pollutant emissions, i.e. COD, ammonia nitrogen, sulfur dioxide, and nitrogen oxides, this paper quantitatively evaluates the county environmental stress intensity of human activities and analyzes its point-line-plane spatial effects in the Qinghai-Tibet Plateau national park cluster. As is shown in the results: the emission of anthropogenic pollutants has a low degree of environmental stress to the Sanjiangyuan region, but shows significantly spatial differentiation characteristics. The central cities (towns) have high stress intensity and the four counties of Maduo, Zaduo, Zhiduo and Qumalai where the national park is located have only 1/2 the average stress intensity. From 2012 to 2016, the regional pattern of spatial effects shows a complex of points, lines, and planes. Points indicate the effects of urbanization and industrialization; lines indicate tourism and transportation; and planes indicate agricultural and animal husbandry production. It is suggested developing managing and responding measures to alleviate the environmental stress in the Qinghai-Tibet Plateau national park cluster from the aspects of improvement of the carrying capacity of all-factor environmental facilities, establishment of a full-covering functional zoning control system, and implementation of whole-process environmental regulations for productional, living and touristic activities.