In the context of human activities have become the primary factor in the contradiction between human and land, examining the interaction between human activities and natural environment from spatial correlation perspective is an essential premise for promoting regional sustainable development. Using data in 2015, this paper has constructed a comprehensive evaluation index system composed of natural environment and human activities. We have employed wavelet multiscale analysis, bivariate local spatial autocorrelation analysis, and man-land system coupling harmonious degree model to explore spatial correlation, spatial matching, and spatial coupling relationships between human and land in the continent of China. The results are as follow:(1) The higher the scale of territory, the stronger the spatial correlation between human activities scale and natural geographic foundation is, which indicates the natural environment impacts on human activities at a fundamental level. (2) The spatial matching between human activities scale and the natural resource support shows an unbalanced characteristic. In particular, the north China has being confronted with severe challenges of regional sustainable development, which results from the significant mismatch relationship between human activities scale and the natural resource support. (3) The spatial coupling harmonious degree of the relationship between human activities effect and natural environment carrying capacity decreases from the southeast to the northwest in China. It is a rational choice to defuse the regional contradiction between human and land by adjusting the structure of and the way in which human carry out activities.