With the acceleration of economic and social development, competition among multi-functional spaces is continuously enhanced, and coordination and stability of territorial space are seriously affected. Therefore, it is of great significance to simulate the spatial conflict pattern of production-living-ecological spaces and analyse its evolutionary characteristics for scientific utilization of territorial space and optimization of regional development patterns. In this paper, Changli County is taken as the research area. Based on the data of land use status for two years (2005, 2015), CLUE-S model is used to predict the land use patterns in the research area in 2025. Based on the leading and secondary functions of land use, the territorial space is divided into living-production space, production-ecological space, ecological-production space, and ecological space. Based on the landscape ecological index, a spatial conflict measurement model is constructed to estimate the changing trend of the production-living-ecological spatial conflict in Changli County from 2005 to 2025. The results show that:(1) From 2005 to 2025, the territorial space of Changli County is dominated by production-ecological space. At the end of 2015, the living-production space and the production-ecological space occupy a large amount of ecological-production space and ecological space, especially near the river. By 2025, there will be fewer changes in each spatial type, but the amount of living-production space will still be relatively large. (2) From 2005 to 2025, the level of spatial conflict in Changli County will be on the rise, and by 2025, spatial conflict will gradually be dominated by strong spatial conflict. This is due to the production-ecological space and the living-production space expanding outward ceaselessly. With the acceleration of urbanization and industrial development, the outward expansion of the living-production space and the production-ecological space will gradually increase, and the ecological-production space and the ecological space will face threats.